Pyxis Diagnostics Technology
basic-triangle-bottom.png

Our Technology

Pyxis technology combines proprietary identification, quantification and purification of up to 30 immune, stroma and cancer cell populations from tumor biopsies. This is coupled with deep gene expression profiling of the purified cell populations. The unique high-resolution cellular and transcriptomic data collected is analyzed using machine learning approaches, which infer the inter-cellular communication network formed between different cell subsets found within the tumor.

From inter-cellular communication networks to predictive diagnostics and target discovery

Individual patients’ inter-cellular communication network

Tumor

tumor
arrow

Viable tumor dissociation

Viable tumor dissociation

Flow cytometric sorting of tumor and immune cells

arrow
RNA sequencing library

RNA sequencing library

arrow
Immune cells net
Responders

Responders

Biomark Identification

responders and non responders
arrow
arrow
Non-responders

Non-Responders

New drug combinations and/or new targets

network2-03.png

Why is it so complex to find predictive biomarkers?

The fate of immunotherapy response is directed by the immune system, the tumor, and its microenvironment.

 

Accurate prediction requires deep understanding of the communication network of these three components - while Pyxis is the only company to implement this approach in this field

Many different cell types that can interact via direct contact or secretion of cytokine/chemokines

Many different cell types that can interact via direct contact or secretion of cytokine/chemokines
Many suppressive layers in tumors can regulate the immune response

Many suppressive layers in tumors can regulate the immune response